Postoperative Complications in Major Surgery

Starting soon

Conditions studied: Major Surgery

In brief

The primary objective of this study is to develop and validate a multivariable risk prediction model for 30-day major postoperative complications and mortality in patients undergoing major surgery across participating international centers. Despite advancements in perioperative care, surgical complications remain a leading cause of global morbidity and preventable death, particularly in resource-limited or low- and middle-income country (LMIC) settings. This study utilizes a prospective, multicenter, international cohort design. Data will be collected on patient-level risk factors (e.g., age, frailty, comorbidities), hospital-level infrastructure (e.g., nurse-to-patient ratios, rescue capacity), and perioperative safety processes (e.g., adherence to the WHO Surgical Safety Checklist). Patients will be followed prospectively for up to 30 days post-surgery. The collected data will be used to construct robust predictive models to identify individual patient risk and uncover actionable system-level factors to optimize surgical safety globally.

Key facts

Study ID

NCT07621198

Run by

Hospital Departamental de Villavicencio

People needed

364

Starts

2026-08-01

Expected to finish

2027-08-30

Last updated by the study team

2026-06-02

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Major surgery
• Adult or pediatric patients
• Emergency or elective surgery
• Ambulatory or hospitalized patients

You may not qualify if…

• Patients derived to other institution

Where it is running

• Hospital Departamental de Villavicencio — Villavicencio, Meta Department, Colombia

Full record on ClinicalTrials.gov

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