Opiranserin for Minimally Invasive Cholecystectomy

Recruiting now · Not applicable

Conditions studied: Cholecystectomy, Laparoscopic, Cholecystectomy, Robotic

In brief

The purpose of this study is to evaluate whether the combination therapy of opiranserin and acetaminophen is non-inferior to the combination of non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen for postoperative pain management after minimally invasive cholecystectomy. This is a single-center, randomized, controlled, non-inferiority clinical trial in adult patients undergoing minimally invasive cholecystectomy. Participants will be randomly assigned to either the Treatement group (opiranserin + acetaminophen) or the control group (NSAIDs + acetaminophen) in a 1:1 ratio to compare the analgesic efficacy and safety between the two analgesic regimens.

Key facts

Study ID

NCT07620665

Run by

Gangnam Severance Hospital

People needed

88

Starts

2026-06-10

Expected to finish

2028-05-30

Last updated by the study team

2026-06-18

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient undergoing minimally invasive cholecystectomy

You may not qualify if…

• Known hypersensitivity or allergy to acetaminophen, NSAIDs, opiranserin, or fentanyl.
• pre-existing chronic pain,
• clinically significant ECG findings (QRS > 200 msec, QTcF >450 msec)
• severe renal impairment
• severe hepatic impairment

Where it is running

• Gangnam Severance Hospital — Seoul, South Korea (enrolling)
• Gangnam Severance Hospital — Seoul, South Korea

Full record on ClinicalTrials.gov

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