Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery

Starting soon

Conditions studied: Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction, Hemodynamic Changes, Mechanical Ventilation

In brief

Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.

Key facts

Study ID

NCT07619274

Run by

Laval University

People needed

220

Starts

2026-05-01

Expected to finish

2026-10-01

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previously included and complete study NCT05886413 or NCT06826794

You may not qualify if…

• Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
• Absence of arterial blood gas on arrival to the intensive care unit

Where it is running

• Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval — Québec, Quebec, Canada

Full record on ClinicalTrials.gov

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