Proximal Nerve Cryoablation Versus Perineuroma Cryoablation for Chronic Neuroma Pain After Combat-Related Amputation
Starting soon · Not applicable
Conditions studied: Neuroma, Cryoablation
In brief
atients with combat-related amputations frequently develop chronic neuroma pain that interferes with rehabilitation, prosthesis use, mobility, sleep, and quality of life. Cryoablation is a minimally invasive treatment that produces controlled nerve injury using extreme cold. Although the freezing effect is localized around the cryoprobe, axonal interruption followed by distal Wallerian degeneration may extend functional denervation distal to the ablation site. This study aims to compare two ultrasound-guided cryoablation strategies for chronic neuroma pain after combat-related amputation: cryoablation performed directly near the neuroma and cryoablation performed proximal to the neuroma along the affected nerve. The study will evaluate whether proximal nerve cryoablation produces greater or longer-lasting analgesic effects compared with perineuroma cryoablation.
Key facts
- Study ID
- NCT07618689
- Run by
- Ukrainian Society of Regional Anesthesia and Pain Therapy
- People needed
- 50
- Starts
- 2026-10-15
- Expected to finish
- 2026-10-15
- Last updated by the study team
- 2026-06-02
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Combat-related limb amputation
- Chronic neuroma pain lasting ≥3 months
- Ultrasound-confirmed painful neuroma
- Average pain intensity ≥4/10 on Numeric Rating Scale
- Positive Tinel sign
- Ability to undergo ultrasound-guided cryoablation
- Stable analgesic regimen for at least 14 days
- Ability to provide written informed consent
You may not qualify if…
- Active infection at the treatment site
- Open wound preventing safe procedure
- Previous cryoablation of the target nerve within 6 months
- Neuroma surgery within 3 months
- Severe coagulopathy or anticoagulation contraindicating procedure
- Pregnancy or breastfeeding
- Severe uncontrolled systemic disease
- Inability to complete follow-up assessments
Where it is running
- Vinnitsya university hospital — Vinnytsia, Вінницька, Ukraine
Full record on ClinicalTrials.gov
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