The 50:50 Nitrous Oxide vs 2% Lidocaine Challenge

Recruiting now · Not applicable

Conditions studied: Acute Pain, Anxiety, Central Venous Catheter

In brief

The main goal of the project is to assess pain levels and patient comfort during the administration of a 50:50 Nitrous Oxide/Oxygen gas mixture, in comparison to the same parameters under the standard method used at our institution, which includes injecting a local anaesthetic at the site of planned puncture for central venous catheterisation.

Key facts

Study ID

NCT07618676

Run by

Institute for Oncology and Radiology of Serbia

People needed

62

Starts

2025-06-06

Expected to finish

2026-07-01

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects who have not previously received Nitrous Oxide.
• Subjects of both sexes, aged between 18 and 65 inclusive.
• Subjects who have signed informed consent with full disclosure; no study-related procedure may begin until the subject signs the consent form.

You may not qualify if…

• Infection at the planned puncture site.
• Pregnancy.
• Intracranial hypertension.
• Vitamin B12 deficiency.
• Hemodynamic instability.
• BMI over 35.
• Glasgow Coma Scale (GCS) score less than 15.
• Presence of chronic pain.
• Neurological disorders.
• Hematologic disorders.
• More than two attempts at venous puncture (Subject Withdrawal Criterion).
• Subject experienced an adverse event requiring early discontinuation (Subject Withdrawal Criterion).
• Withdrawal of consent by the subject (Subject Withdrawal Criterion)

Where it is running

• Institute for Oncology and Radiology of Serbia — Belgrade, Savski Venac, Serbia (enrolling)

Full record on ClinicalTrials.gov

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