Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study

Recruiting now

Conditions studied: Atrial Fibrillation (AF), Tricuspid Regurgitation (TR)

In brief

This is a prospective, observational, multicenter study aimed at characterizing tricuspid valve remodeling in patients with atrial fibrillation (AF) without significant tricuspid regurgitation (TR), in relation to AF burden progression.

Key facts

Study ID

NCT07617974

Run by

Centro Cardiologico Monzino

People needed

66

Starts

2026-05-04

Expected to finish

2027-05-31

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Consecutive patients with atrial fibrillation (paroxysmal or persistent) undergoing transthoracic echocardiography (TTE) prior to AF ablation with acquisition of a 3D TV dataset.
• Eligible for enrollment in the control group will be:
• all consecutive patients with structurally normal hearts and no history of AF or;
• moderate atrial functional tricuspid regurgitation and AF, in the absence of significant left-sided valvular disease or prior valvular surgery.

You may not qualify if…

• Moderate or greater TR assessed using a multiparametric approach;
• Arrhythmias other than AF;
• Prior AF ablations;
• Rapid ventricular response (average HR >110 bpm) during baseline TTE;
• Inadequate image quality

Where it is running

• Centro Cardiologico Monzino; IRCCS — Milan, Milan, Italy (enrolling)

Full record on ClinicalTrials.gov

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