L-Citrulline Versus Tamsulosin for Medical Expulsive Therapy of Distal Ureteral Stones

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Distal Ureteral Stone, Urolithiasis, Ureteral Calculi

In brief

This study will compare L-citrulline and tamsulosin as medical expulsive therapy for adults with single distal ureteral stones. Eligible participants with a single distal ureteral stone measuring 5 to 10 mm will be randomly assigned to receive either oral L-citrulline 750 mg twice daily or oral tamsulosin 0.4 mg once daily. Treatment will continue until documented stone passage or completion of 4 weeks of therapy, whichever occurs first. Participants will be followed weekly for up to 4 weeks. The main outcome is stone expulsion within 4 weeks. The study will also assess time to stone expulsion, pain episodes, analgesic use, need for additional intervention, and adverse events.

Key facts

Study ID: NCT07617909
Run by: Beni-Suef University
People needed: 120
Starts: 2026-05-06
Expected to finish: 2026-11-01
Last updated by the study team: 2026-06-01

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18 to 60 years.
Single distal ureteral stone.
Stone size 5 to 10 mm.
Normal renal function.
Controlled pain.
Willingness to comply with follow-up for 4 weeks.
Written informed consent.

You may not qualify if…

Fever or active urinary tract infection.
Severe hydronephrosis.
Solitary kidney.
Pregnancy.
Previous ureteric surgery.
Multiple ureteral stones.
Indication for urgent surgical intervention.
Known hypersensitivity or contraindication to L-citrulline or tamsulosin.
Inability to complete follow-up.

Where it is running

Department of Urology- Beni-Suef University Hospitals — Banī Suwayf, Beni Suweif Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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