A Phase I Study of JSKN021 in Advanced Solid Tumors

Recruiting now · Phase 1

Conditions studied: Advanced Malignant Solid Tumors

In brief

This is a Phase I, open-label, multi-center, first-in-human (FIH) clinical trial designed to evaluate the safety, tolerability, pharmacokinetic (PK) profiles, and the preliminary antitumor activity of JSKN021 in advanced malignant solid tumors.

Key facts

Study ID

NCT07617727

Run by

Jiangsu Alphamab Biopharmaceuticals Co., Ltd

People needed

199

Starts

2026-06-02

Expected to finish

2029-05-31

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Voluntarily participate and sign the informed consent form.
• Age ≥ 18 and ≤ 75 years old, male or female.
• Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0 or 1.
• Expected survival ≥ 3 months.
• Histologically or cytologically confirmed malignant solid tumors confirmed by histology and/or cytology, who have failed previous standard treatment (disease progression), are intolerant to standard treatment, or have no access to standard treatment.
• At least one measurable lesion at baseline according to RECIST 1.1 criteria.
• Adequate organ function.
• Female subjects of childbearing potential or male subjects whose partners are of childbearing potential agree to use effective contraceptive measures.
• Female subjects of childbearing potential must have a negative serum/urine pregnancy test within 7 days before the first dose.
• Be able and willing to comply with the visits, treatment plans, laboratory tests, and other study-related procedures specified in the study protocol.
• Adequate washout period of previous therapy before the first dose.

You may not qualify if…

• Complicated with other malignant tumors within 3 years before the first dose.
• History of brainstem, meningeal metastasis, spinal cord metastasis or compression, or carcinomatous meningitis; presence of active brain metastasis.
• Screening imaging shows tumor invasion, compression, or occurrence in surrounding important organs or risk of esophagotracheal fistula or esophagopleural fistula.
• Presence of clinically severe respiratory impairment caused by pulmonary disease complications.
• Presence of the risk factors related to interstitial lung disease (ILD) or non-infectious pneumonia:
• Presence of cardiovascular and cerebrovascular diseases or cardiovascular and cerebrovascular risk factors.
• Uncontrolled infection.
• Received live vaccines within 28 days before the first dose, or plan to receive live vaccines during the study period.
• Toxicity of previous anti-tumor treatment has not fully or partially recovered.
• Known allergy to any component of the study drug, or history of severe allergic reactions to other antibody drugs.
• Pregnant and/or lactating women, or planning to become pregnant during the study period.
• Known history of mental illness, substance abuse, alcoholism, etc., or other situations that the investigator deems may affect the safety or compliance of the study drug treatment.

Where it is running

• Tumor Hospital of Guangxi Medical University — Nanning, Guangxi, China (enrolling)
• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (enrolling)
• Jiangsu Province Hospital — Nanjing, Jiangsu, China (enrolling)
• Xuzhou Central Hospital — Xuzhou, Jiangsu, China (enrolling)
• Affiliated Hospital of Jining Medical College — Jining, Shandong, China (enrolling)
• Fudan University Shanghai Cancer Center — Shanghai, Shanghai Municipality, China (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.