Neural Basis of Human Working Memory

Recruiting now · Not applicable

Conditions studied: Memory Disorders

In brief

This ClinicalTrials.gov entry corresponds to the Neural Basis of Human Working Memory protocol approved under Vanderbilt University Medical Center IRB #251231. This study investigates the neural activity underlying human working memory, via local field potential changes (macro level) and/or single neuronal spiking changes (micro level) from depth electrodes placed for invasive seizure monitoring. Subjects will complete neurocognitive tasks while neural recordings are collected. Some patients will complete neurocognitive tasks while stimulation is applied via depth electrodes. Further understanding the neural activity changes underlying normal and impaired working memory may help to identify novel diagnostic methods and treatments for impaired working memory and may support the use of stimulation for treatment of memory disorders.

Key facts

Study ID

NCT07617506

Run by

Vanderbilt University Medical Center

People needed

100

Starts

2025-06-04

Expected to finish

2027-04-01

Last updated by the study team

2026-07-31

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing SEEG monitoring at Vanderbilt University Medical Center
• Age >18
• English speaking

You may not qualify if…

• Age <18
• Not able to complete questionnaires (unable to comprehend instructions or follow directions)

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)

Full record on ClinicalTrials.gov

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