EIT Evaluation of the Impact of Inhaled Nitric Oxide on Ventilation/Perfusion Mismatch in ARDS Patients Receiving Noninvasive Respiratory Support
Starting soon
Conditions studied: ARDS (Acute Respiratory Distress Syndrome)
In brief
This study aimed to quantitatively evaluate the immediate effect of inhaled nitric oxide on the ventilation / perfusion ratio in ARDS patients receiving nasal high flow oxygen therapy or noninvasive ventilation using electrical impedance tomography.
Key facts
- Study ID
- NCT07617298
- Run by
- Ming Zhong
- People needed
- 40
- Starts
- 2026-06-30
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-06-01
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years, gender unlimited;
- Non invasive ventilation (NIV) with PEEP or CPAP ≥ 5 cmH2O or nasal high flow oxygen therapy (hfnc) with flow rate ≥ 30 l/min met the diagnostic criteria of non intubated ARDS according to the new global definition of ARDS: pao2/fio2 ≤ 300MMHG or spo2/fio2 ≤ 315 (SpO2 ≤ 97%);
- Patients with spontaneous breathing and clear consciousness can cooperate with instructions and hold breath for ≥ 8s;
- Patients with spontaneous breathing and clear consciousness can cooperate with instructions and hold breath for ≥ 8s;
You may not qualify if…
- There are signs of worsening respiratory failure requiring immediate intubation: respiratory rate > 40 times / min with severe use of auxiliary respiratory muscles or contradictory breathing, or Paco ₂ > 50 mmHg and pH < 7.25;
- Hemodynamic instability or the presence of refractory shock; That is, the vasoactive drugs increased by more than 30% within 6 hours, or the norepinephrine dose exceeded 0.5 μ g /kg/min;
- There are contraindications to EIT monitoring, such as thoracic implantable defibrillator / pacemaker, large area of severe skin damage on the chest, serious allergy to electrode patches, etc;
- There are contraindications to the use of iNO: such as severe left ventricular dysfunction, active bleeding, etc;
- Patients with intracranial hypertension, severe arrhythmia or digestive tract obstruction;
- Pneumothorax and massive pleural effusion were not treated;
- Chronic kidney disease;
- Pregnant or lactating women;
- Participating in other studies;
- The investigator judged that there were any other circumstances not suitable for participation in this study. -
Where it is running
- Nitric Oxide Therapy Device — Shanghai, China
Full record on ClinicalTrials.gov
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