RDW and RV-PA Coupling in Acute PE

Starting soon

Conditions studied: Pulmonary Embolism Acute

In brief

Prior work linking RDW to echocardiographic findings in PE has largely focused on isolated parameters such as TAPSE or PASP and has rarely incorporated modern measures of RV-PA coupling. Whether admission RDW reflects the integrated RV-PA interaction - and not merely contractility or pressure in isolation - has not been adequately addressed. Establishing this link would support RDW as a simple, universally available marker of RV vulnerability at first presentation, and would lay the groundwork for future prognostic and mechanistic studies.

Key facts

Study ID

NCT07616557

Run by

Assiut University

People needed

190

Starts

2026-06-15

Expected to finish

2027-12-15

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years. Acute PE confirmed by computed tomography pulmonary angiogram (CTPA) performed within 24 h of presentation.
• CBC obtained within 24 h of admission and before any blood transfusion. Transthoracic echocardiography feasible within 24 h of admission. Written informed consent.

You may not qualify if…

• Active hematologic malignancy or recent chemotherapy with myelosuppressive intent.
• Red blood cell transfusion within the preceding 90 days.
• Known hemoglobinopathy (e.g., sickle cell disease, thalassemia major).
• Chronic dialysis or eGFR < 15 mL/min/1.73 m².
• Pre-existing severe pulmonary hypertension (resting mean PAP ≥ 35 mmHg by prior right heart catheterization or echocardiographic PASP ≥ 60 mmHg before this admission), severe left-sided valvular disease, or known severe biventricular dysfunction.
• Hemodynamic instability requiring vasopressors at the time of echocardiography, as their hemodynamics may distort RV-PA coupling estimates.
• Inadequate echocardiographic image quality precluding measurement of TAPSE and a quantifiable TR jet for PASP estimation.
• Inability to provide informed consent.

Full record on ClinicalTrials.gov

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