Dynamic Trajectories of Pupillary Light Reflex Parameters and Prognosis in Critically Ill Patients: A Multicenter Prospective Cohort Study
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Conditions studied: Critical Illness, Pupillometry, Prognosis
In brief
This multicenter prospective observational cohort study aims to investigate the association between early dynamic trajectories of pupillary light reflex parameters and clinical outcomes in critically ill patients admitted to emergency intensive care units. Quantitative pupillometry will be performed during the first 7 days after EICU admission. Constriction velocity will be the primary parameter for trajectory analysis, while dilation velocity, pupil diameter, constriction percentage, maximum constriction velocity, and latency will be analyzed as supplementary parameters. The study will evaluate whether these dynamic pupillary trajectories are associated with discharge outcome and 90-day functional outcome assessed by the Glasgow Outcome Scale-Extended.
Key facts
- Study ID
- NCT07616518
- Run by
- Second Affiliated Hospital, Zhejiang University, School of Medicine
- People needed
- 700
- Starts
- 2026-06-06
- Expected to finish
- 2026-10-13
- Last updated by the study team
- 2026-06-01
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older.
- Admission to the emergency intensive care unit.
- Critically ill patients with an expected EICU stay longer than 48 hours.
- Written informed consent obtained from the participant or legally authorized representative.
You may not qualify if…
- Severe ocular disease, severe ocular trauma, postoperative ocular status, or other conditions that prevent reliable pupillary measurement.
- Known neuro-ophthalmic disorders that may affect the pupillary light reflex, such as oculomotor nerve palsy.
- Use of topical ophthalmic medications during the study period that may significantly affect pupillary response, when their effects cannot be accurately recorded or evaluated.
- Pregnancy or breastfeeding.
Full record on ClinicalTrials.gov
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