Higher Radiation Dose to the Tumor May Help Avoid Surgery in Rectal Cancer Patients

Recruiting now · Not applicable

Conditions studied: Rectal Cancer, Radiation Oncology

In brief

The goal of this prospective study is to evaluate if a higher radiation dose to the tumor can increase the organ preservation rate in non-locally advanced rectal cancer.

Key facts

Study ID

NCT07616297

Run by

Claudia Schuurhuizen

People needed

25

Starts

2026-01-27

Expected to finish

2030-08-01

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Eastern cooperative oncology group (ECOG) performance status ≤2
• Histologically confirmed rectal adenocarcinoma
• Non-locally advanced rectal cancer, defined as (magnetic resonance imaging (MRI)-based) T1-3, N0/N1 (≤3 positive mesorectal lymph nodes), MX/M0
• Indication for curative treatment with organ preservation
• Discussed in the multidisciplinary tumor board (MTB)
• Written informed consent

You may not qualify if…

• Previous radiotherapy in the pelvic area
• Other malignancies, except for adequately treated basal cell carcinoma (BCC), at time of inclusion or within 3 years prior to inclusion
• Contra-indications for (chemo)radiotherapy or surgery
• Presence of lateral lymph nodes, cN2 status, extramural vascular invasion (EMVI) or mesorectal fascia involvement as seen on MRI
• Mucinous defined tumor on MRI
• Prior local excision of the primary tumor
• DPD (dihydropyrimidine dehydrogenase) deficiency
• Unable to understand the requirements of the study and to give written informed consent, as determined by the treating physician

Where it is running

• Erasmus MC — Rotterdam, South Holland, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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