Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

Starting soon · Not applicable

Conditions studied: Post-stroke, Parkinson Disease, Amyotrophic Lateral Sclerosis, Mild Cognitive Impairment (MCI), Multiple Sclerosis, Frailty at Older Adults

In brief

The purpose of this clinical study is to evaluate the feasibility, usability, and motivational impact of VirtualPark, a virtual reality-based dual-task rehabilitation system, in adults with neurological and age-related conditions. VirtualPark is a virtual reality application designed to deliver cognitive exercises during cycling training using a commercially available ergometer (THERA-Trainer Tigo). The system integrates physical and cognitive tasks in simulated real-life environments. The intervention integrates motor and cognitive training tasks targeting domains such as attention, inhibition, working memory, and navigation. This is a prospective, multicenter, randomized, cross-over pilot study. It will compare cycling training performed with and without virtual reality. Participants will complete both intervention conditions over a 4-week period separated by a wash-out phase with standard rehabilitation activities. The order of conditions will be randomized. The study will assess motivation during rehabilitation training, usability and user experience of the system, as well as exploratory effects on cognitive and motor performance, functional abilities, perceived exertion, and safety. The study will enroll adult participants (≥18 years) with conditions such as stroke, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, mild cognitive impairment, spinal cord injury, and frail older adults.

Key facts

Study ID: NCT07616050
Run by: Marta Mondellini
People needed: 70
Starts: 2026-06-01
Expected to finish: 2027-01-01
Last updated by the study team: 2026-05-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Informed consent to the study
subjects > 18 years and <85 years
diagnosis of MCI according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders VTh Edition (DSM V TR American Psychological Association 2013)
detection of ischemic stroke within 6 months preceding the study, frail elderly subjects (Gobbens RJ et al. 2010)
subjects affected by idiopathic Parkinson's disease according to the MDS-PD criteria (Postuma et al., 2015)
subjects affected by possible, probable and definite ALS according to the revised El Escorial criteria (Brooks Br, et al. 2000)
subjects affected by MS according to the McDonald criteria (2017) with disability measured with the EDSS (Expanded Disability Status Scale) <= 8
patients with spinal cord injury of different etiology with incomplete spinal cord injury, AIS (ASIA impairment scale) grade C and D, MMSE >18
subjects naïve to the use of the RV
no therapeutic changes or rehabilitation interventions in the month prior to inclusion in the study
no ongoing behavioral disorders.

You may not qualify if…

Other concomitant neurological pathologies in addition to the one under study
presence of visual disturbances that do not allow access to the experimental virtual reality protocol
presence of impaired cardiorespiratory function or other organic instabilities that contraindicate ergometer training
severe osteoporosis

Where it is running

Istituti a Carattere Scientifico Maugeri Bari — Bari, Bari, Italy
Istituti a Carattere Scientifico Maugeri Telese — Telese Terme, Benevento, Italy
Centro di Riabilitazione Villa Beretta — Costa Masnaga, Lecco, Italy
Istituti a Carattere Scientifico Maugeri Milano Camaldoli — Milan, Milano, Italy
Istituti a Carattere Scientifico Maugeri Montescano — Montescano, Pavia, Italy
Istituti a Carattere Scientifico Maugeri Pavia — Pavia, Pavia, Italy
Università di Pisa — Pisa, Pisa, Italy

Full record on ClinicalTrials.gov

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