The Efficacy and Safety of Female PRP Co-incubation With Sperm During (IUI) Cycles
Starting soon · Not applicable
Conditions studied: Reproductive Issues
In brief
The investigators hypothesize that infertility patients undergoing IUI who receive female autologous platelet-rich plasma (PRP) co-incubation with husband's sperm would have higher clinical pregnancy rate. Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing IUI with female PRP co-incubation with husband's sperm group and non-PRP group. Secondary outcomes: * To evaluate the post-culture sperm parameters between the intervention group and control group * To evaluate the IUI parameter between the intervention group and control group * To evaluate the safeness between the female PRP co-incubation with husband's sperm in the IUI group and non-PRP group, including potential infection rate or other pregnancy outcomes such as miscarriage, multiple pregnancy, ectopic pregnancy and molar pregnancy
Key facts
- Study ID
- NCT07615634
- Run by
- Chinese University of Hong Kong
- People needed
- 288
- Starts
- 2026-05-21
- Expected to finish
- 2028-05-20
- Last updated by the study team
- 2026-05-29
Who can join
Age: 18 and older, up to 42. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients who were eligible for IUI cycles in Assissted Reproduction Technolog unit, Prince of Wales Hospital
- Female patients aged >18 years old and < 42 years old
- BMI < 30 kg/m2
You may not qualify if…
- Concurrent administration of other agents such as prednisolone, intravenous immunoglobulin, or G-CSF
- Administration of anticoagulants or NSAIDs at least 7 days before PRP infuse
- Drug addiction
- Untreated urinary tract infection
- Underlying uncontrolled diabetes or hypertension, chromosomal or uterine abnormalities, genetic, hematologic, immunological, or endocrine disorders
- Chronic disease, systemic disease or cancers
- Blood diseases (sepsis, thrombocytopenia)
- Poor sperm samples (raw sample TMS <5 x 106)
- Smoking and drinking alcoholic beverages on the day of IUI
- Fever on the day of IUI
- Redduse or incomplete in obtaining informed consent
Where it is running
- The Chinese University of Hong Kong — Hong Kong, China
Full record on ClinicalTrials.gov
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