Dexamethasone to Prevent Side Effects of Spinal Anesthesia in Cesarean Delivery

Enrolling by invitation · Phase 4 · Has a placebo group

Conditions studied: Hypotension During Cesarean Delivery, Postoperative Nausea and Vomiting (PONV), Pain, Postoperative

In brief

The goal of this clinical trial is to evaluate the effectiveness of intravenous dexamethasone in preventing adverse effects of spinal anesthesia and prolonging postoperative analgesia in parturients undergoing elective cesarean delivery. The main questions it aims to answer are: Does intravenous dexamethasone reduce the incidence of post-spinal hypotension? Does intravenous dexamethasone reduce the incidence of postoperative nausea and vomiting (PONV)? Does intravenous dexamethasone prolong the duration of postoperative analgesia? Researchers will compare intravenous dexamethasone (8 mg) to a placebo (0.9% saline) to see if dexamethasone effectively prevents post-spinal hypotension and PONV, and improves postoperative pain relief. Participants will: Receive an intravenous injection of either 8 mg dexamethasone or a placebo (2 mL 0.9% saline) prior to receiving spinal anesthesia. Have their blood pressure recorded frequently (every minute for the first 20 minutes, then every 5 minutes until the completion of surgery). Undergo sensory block assessment (via cold testing) and motor block evaluation (using the Bromage scale). Have maternal glycemia and neonatal safety monitored for potential steroid-related adverse effects.

Key facts

Study ID

NCT07615595

Run by

University Medical Center Ho Chi Minh City (UMC)

People needed

176

Starts

2025-08-01

Expected to finish

2027-07-31

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• Singleton pregnancy
• Gestational age ≥ 37 weeks
• American Society of Anesthesiologists (ASA) physical status classification of II-III
• Planned for elective cesarean delivery under spinal anesthesia

You may not qualify if…

• Gestational diabetes mellitus or pre-existing (chronic) diabetes mellitus
• Gestational hypertension or chronic hypertension
• Body mass index (BMI) ≥ 35 kg/m²
• Known allergy to dexamethasone
• Current long-term corticosteroid therapy
• Diagnosis of postpartum hemorrhage

Where it is running

• University Medical Center Ho Chi Minh City (UMC) - Campus 2 — Ho Chi Minh City, Ho Chi Minh, Vietnam

Full record on ClinicalTrials.gov

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