Nitric Oxide Consumption as a Predictor of Vasospasm in Subarachnoid Hemorrhage

Recruiting now

Conditions studied: Aneurysmal Subarachnoid Hemorrhage, Cerebral Vasospasm

In brief

The goal of this observational study is to understand if angiographic cerebral vasospasm (CV) can be predicted by levels of nitric oxide (NO) consumption in patients with aneurysmal subarachnoid hemorrhage (SAH). To reach this goal, the investigators will compare NO consumption levels in SAH and non-SAH patients. NO consumption levels will be analyzed from samples of participants' cerebral spinal fluid (CSF).

Key facts

Study ID

NCT07614906

Run by

Massachusetts General Hospital

People needed

40

Starts

2024-03-03

Expected to finish

2027-06-01

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult
• patient with SAH and with an external ventricular drainage (EVD) placed within 24 hours after the onset of the hemorrhage

You may not qualify if…

• pregnancy
• pre-existing neurological comorbidities
• coagulation disorders
• anemia
• absence of a good cranial window to perform Transcranial Doppler (TDC)
• presence of >50% stenosis of carotid arteries confirmed by doppler ultrasound
• Technical problems on EVD that prevent CSF withdrawals
• For the control group, we will invite to participate patients without neurological comorbidities undergoing spinal anesthesia in the operating room or with a spinal drain for major vascular surgery.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States (enrolling)
• Fondazione Policlinico Universitario Agostino Gemelli — Rome, Italy (enrolling)

Full record on ClinicalTrials.gov

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