Exparel and Dexamethasone

Starting soon · Phase 4

Conditions studied: Postoperative Pain, Shoulder Arthroscopic Surgeries

In brief

This prospective randomized clinical trial evaluates the duration of sensory blockade in patients undergoing shoulder surgery receiving interscalene brachial plexus blocks with either liposomal bupivacaine alone or liposomal bupivacaine combined with dexamethasone.

Key facts

Study ID

NCT07614802

Run by

Duke University

People needed

80

Starts

2026-08-01

Expected to finish

2027-09-01

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 80 years
• ASA physical status 1-3
• Undergoing primary shoulder surgery with interscalene nerve block

You may not qualify if…

• ASA 4 or 5
• Revision shoulder surgery
• Daily chronic opioid use (over 3 months of continuous opioid use)
• Inability to communicate pain scores or need for analgesia
• Infection at the site of block placement
• Age under 18 years old or greater than 80 years old
• Pregnant women (as determined by point-of-care serum bHCG)
• Intolerance/allergy to local anesthetics
• Weight <50 kg
• BMI > 40
• severe pulmonary disease including chronic obstructive pulmonary disease and restrictive lung disease
• Suspected, or known addiction to or abuse of illicit drug(s), prescription medicine(s), or alcohol within the past 2 years.
• Uncontrolled anxiety, schizophrenia, or other psychiatric disorder that, in the opinion of the investigator, may interfere with study assessments or compliance.
• Current or historical evidence of any clinically significant disease or condition that, in the opinion of the investigator, may increase the risk of surgery or complicate the subject's postoperative course.

Full record on ClinicalTrials.gov

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