AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing
Recruiting now
Conditions studied: Menopause, Gut Microbiome, Hormonal Changes, Chronic Low-Grade Inflammation, Inflammaging
In brief
AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause. The study will include healthy women aged 40 to 64 years living in Portugal, who will provide stool and blood samples and complete questionnaires about their health, lifestyle, diet, and menopausal symptoms. Researchers will study the gut microbiome together with hormone levels and markers of inflammation to better understand how menopause affects long-term health and to support the development of improved prevention strategies for women.
Key facts
- Study ID
- NCT07614542
- Run by
- Gulbenkian Institute for Molecular Medicine
- People needed
- 300
- Starts
- 2025-06-02
- Expected to finish
- 2036-12-01
- Last updated by the study team
- 2026-05-29
Who can join
Age: 40 and older, up to 64. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female sex
- Aged 40 to 64 years
- Resident in mainland Portugal or the islands
- Able and willing to provide written informed consent
- Willing to provide stool and blood samples and complete three questionnaires
You may not qualify if…
- Age below 40 years or 65 years and older
- Inability to give informed consent
- Refusal to provide stool or blood samples or complete questionnaires
- Pregnancy
- Diagnosed gastrointestinal disorders (including inflammatory bowel disease, Crohn's disease, ulcerative colitis, irritable bowel syndrome, chronic diarrhoea of unknown cause, or recurrent Clostridioides difficile infection)
- Active oncological disease
Where it is running
- Gulbenkian Institute for Molecular Medicine, Lisbon — Lisbon, Portugal (enrolling)
Full record on ClinicalTrials.gov
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