Prediction of Local Anaesthetic Dosing During Labour Epidural Analgesia

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Conditions studied: Labour Analgesia

In brief

Epidural analgesia is the gold standard for controlling labour pain. However, labour pain happens during neuraxial analgesia, due to anaesthetic, obstetric, maternal factors. The investigators hypothesized that relevant variables, able to predict the local anaesthetic (LA) requirement during labour, can be identified at admission and each parturient may therefore be accordingly classified in "low-requirement" and "high-requirement". In this way, a predictive score may be developed, and the analgesic regimen may be matched to the individual patient, thus ensuring a timely and appropriate treatment of patients likely to require higher doses of LA, while minimizing potentially side effects of excessive treatment in the low-dose group.

Key facts

Study ID

NCT07614516

Run by

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

People needed

12500

Starts

2026-06-13

Expected to finish

2026-10-31

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Parturients receiving neuraxial analgesia for labour, as clinical practice

You may not qualify if…

• Planned caesarean delivery

Where it is running

• Fondazione Policlinico Universitario A. Gemelli IRCCS — Rome, RM, Italy

Full record on ClinicalTrials.gov

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