Volume-Stable Collagen Matrix Versus Subepithelial Connective Tissue Graft for Multiple Gingival Recessions

Starting soon · Not applicable

Conditions studied: Gingival Recession

In brief

Gingival recession is a clinical condition in which the gingival margin is displaced apically, exposing the root surface. This condition may be associated with esthetic concerns, dentin hypersensitivity, and difficulties in oral hygiene. Subepithelial connective tissue grafting is considered a standard surgical approach for root coverage, but it requires harvesting tissue from the palate, which may increase postoperative discomfort. Volume-stable xenogeneic collagen matrices have been proposed as an alternative biomaterial to reduce the need for a palatal donor site. This randomized controlled clinical trial will compare a volume-stable xenogeneic collagen matrix with an autogenous subepithelial connective tissue graft for the treatment of multiple gingival recessions. Participants will be allocated to one of two treatment groups. The test group will receive root coverage surgery using a volume-stable collagen matrix, while the control group will receive root coverage surgery using a subepithelial connective tissue graft. Clinical, patient-reported, esthetic, and digital outcomes will be assessed at baseline and during follow-up visits up to 12 months. The primary outcome will be the change in gingival recession depth from baseline to 12 months. Secondary outcomes will include keratinized tissue width, gingival thickness, percentage of root coverage, complete root coverage, dentin hypersensitivity, patient-reported satisfaction, early wound healing, and digital volumetric changes assessed by intraoral scanning.

Key facts

Study ID

NCT07613775

Run by

University of Sao Paulo

People needed

40

Starts

2026-10-01

Expected to finish

2027-12-01

Last updated by the study team

2026-06-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older.
• Presence of at least two Cairo RT1 gingival recessions in anterior teeth and/or premolars.
• Gingival recession depth greater than or equal to 2 mm.
• Presence of at least 2 mm of keratinized gingiva apical to the gingival recession.
• Indication for root coverage treatment due to esthetic concern and/or dentin hypersensitivity.
• Sites with non-carious cervical lesions may be included if they are previously restored and, after restoration, present residual gingival recession greater than or equal to 2 mm.
• Good plaque control, defined as full-mouth plaque score and full-mouth marginal gingival bleeding score below 20%.

You may not qualify if…

• Current smokers or individuals who stopped smoking less than 12 months before enrollment.
• Decompensated systemic diseases.
• Pregnancy or lactation.
• Active periodontal disease.
• Untreated root caries.
• Previous mucogingival surgery in the study area.

Where it is running

• School of Dentistry of Ribeirão Preto, University of Sao Paulo — Ribeirão Preto, São Paulo, Brazil

Full record on ClinicalTrials.gov

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