High-Flow Nasal Cannula on Exercise Tolerance in Heart Failure Patients Undergoing Cardiac Rehabilitation

Starting soon · Not applicable

Conditions studied: Heart Failure, Exercise Tolerance (Measured in Minutes), Cardiac Rehabilitation

In brief

The goal of this clinical trial is to learn if a high-flow nasal cannula (HFNC) - a device that delivers warm, humidified air through a small tube placed in the nostrils - can improve exercise tolerance in adults with heart failure (HF) who are entering a cardiac rehabilitation program. The main questions it aims to answer are: Can HFNC help people with heart failure exercise for a longer time during a treadmill test? and does HFNC lower how hard people feel they are working during exercise? Researchers will compare exercise performance with HFNC to exercise performance without HFNC to see if HFNC helps people with HF tolerate exercise better. Participants will: Complete two treadmill exercise tests, one with HFNC and one without, in a randomly assigned order. Wait 48 to 72 hours between the two tests to allow full recovery. Have their heart rate, blood pressure, oxygen level, and breathing rate measured before and after each test.

Key facts

Study ID

NCT07613762

Run by

Universidad de Santiago de Chile

People needed

28

Starts

2026-06-01

Expected to finish

2027-03-01

Last updated by the study team

2026-06-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years or older
• Medical diagnosis of heart failure (documented in clinical record or referral)
• Electrocardiogram performed within the last 6 months
• Functional capacity class II or III according to the New York Heart Association (NYHA) classification
• Stable pharmacological treatment
• Stable and controlled comorbidities
• Available to complete two evaluation sessions
• Able and willing to provide written informed consent

You may not qualify if…

• Diagnosis of respiratory disease (chronic obstructive pulmonary disease, interstitial lung disease, or pulmonary hypertension)
• Myocardial infarction within the past 3 months
• Hospitalization due to heart failure within the past 4 weeks
• Cognitive impairment or inability to follow the study protocol
• Neuromuscular or osteoarticular conditions that limit treadmill test performance

Where it is running

• Complejo Hospitalario San José — Santiago, Santiago Metropolitan, Chile

Full record on ClinicalTrials.gov

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