Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix

Starting soon · Not applicable

Conditions studied: Acellular Dermal Matrix, Bone Grafting, Soft Tissue Grafting

In brief

This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.

Key facts

Study ID

NCT07613047

Run by

University of Alabama at Birmingham

People needed

70

Starts

2026-10-01

Expected to finish

2028-10-01

Last updated by the study team

2026-06-01

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English speaking
• At least 18 years old
• Must be a patient of the UAB Dental School
• Able to read and understand informed consent document
• Patients presenting with a diagnosed need horizontal ridge augmentation with GBR without simultaneous implant placement, to allow for future dental implant placement.
• Presence of periodontally healthy, non-carious neighboring teeth and/or healthy restored dental implants on either side of the edentulous span planned for GBR, or unhealthy adjacent teeth to be extracted during the same visit.
• ≤4 mm ridge width in a Seibert Class I Edentulous span19
• No anticipated need for surgical and/or endodontic care at planned teeth adjacent to the proposed surgical site during the study period.

You may not qualify if…

• Non-English speaking
• Less than 18 years old
• Smokers/nicotine users (defined as currently reporting use of any form of tobacco/nicotine products)
• Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing, including:
• Uncontrolled diabetes (HbA1c > 7%)
• Untreated periodontal disease
• History of head/neck radiation
• IV bisphosphonates
• Immunocompromised state
• Pregnancy
• Acute infection at site
• Documented or suspected allergy or sensitivity to any study product

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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