Tailored Brain Health Insights Through Nurturing Knowledge-based Change - Stakeholder-driven, Human-centered, AI-powered Refinement for Prevention

Starting soon · Not applicable

Conditions studied: MCI, Dementia

In brief

The goal of this clinical trial is to evaluate whether an AI-powered digital brain health coaching intervention can improve modifiable brain health risk factors in community-dwelling adults aged 40 and above in Singapore. The main question it aims to answer is: does the use of BLAZE, an AI-powered digital brain health coaching intervention, lead to a greater improvement in Brain Care Score (BCS) compared to usual care at 6 months? Researchers will compare participants receiving BLAZE to those receiving usual care (waitlist control) to see if BLAZE leads to greater improvements in brain health risk factors, behavioural outcomes, quality of life, and cost-effectiveness. Participants will: * Be randomly assigned to either receive BLAZE immediately for 12 months or be placed on a waitlist receiving usual care for the first 6 months before receiving BLAZE for a further 6 months * Complete a series of assessments at baseline, 6 months, and 12 months including the Brain Care Score, physical function tests, cognitive assessments, quality of life measures, and lifestyle behaviour questionnaires * If assigned to the intervention group, interact with BLAZE via a WhatsApp-based platform that delivers personalised brain health recommendations, behavioural nudges, educational content, and goal-setting support based on their individual Brain Care Score profile

Key facts

Study ID

NCT07612800

Run by

Alexandra Hospital

People needed

350

Starts

2026-09-01

Expected to finish

2029-12-31

Last updated by the study team

2026-05-29

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Community-dwelling adults
• Aged 40 years and above at time of recruitment
• Able to use a smartphone and smartphone applications
• Able to provide written informed consent

You may not qualify if…

• Been diagnosed wotj dementia, neurocognitive disorder or any major psychiatric illness
• Have severe sensory or physical disability precluding usage of the application
• Terminal illness or expected survival of less than 12 months at point of recruitment

Where it is running

• Alexandra Hospital — Singapore, Singapore, Singapore

Full record on ClinicalTrials.gov

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