Elacestrant in Advanced Triple Positive Breast Cancer

Recruiting now · Phase 1/Phase 2

Conditions studied: ER Positive, HER2 Positive Breast Cancer

In brief

The purpose of this study to assess the safety and efficacy of elacestrant, a selective estrogen receptor degrader (SERD) and dual biologic therapy, trastuzumab and pertuzumab, in patients with triple-positive breast cancer with and without an ESR1 mutation.

Key facts

Study ID: NCT07612215
Run by: NYU Langone Health
People needed: 50
Starts: 2026-05-13
Expected to finish: 2030-05-01
Last updated by the study team: 2026-05-28

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Female patients aged 18 years or older.
Should be able to provide the informed consent.
Histologically confirmed diagnosis of triple-positive breast cancer (ER+, PR+, HER2+). In the study, ER status will be considered positive if ≥10% of tumor cells demonstrate positive nuclear staining by immunohistochemistry, with PR>1%. Patients may be considered to be enrolled on study with prior approval of study PI if ER >10% and without PGR positivity HER2 status will be considered positive with the score of 3+ with immunohistochemistry staining or 2+ by immunohistochemistry and FISH -amplified as per ASCO CAP guidelines (2023)"
Disease progression on or after at least one line of NCCN recommended prior therapy
Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
Patient has adequate organ function, as defined by the following laboratory values:
Hematologic Value:
Hemoglobin ≥9.0 g/dL, without transfusion or growth factors within 1 week
Neutrophils ≥1.5×103/μL or ≥1.0×103/μL for participants with benign ethnic neutropenia
Platelets ≥100×103/μL
Patient must have a baseline LVEF ≥50 % or ≥ institutional LLN within 28 days prior to the study treatment.
Sex and Contraceptive/Barrier Requirements
While on study treatment a participant must not breastfeed or be pregnant
Have a negative highly sensitive (eg, beta-human chorionic gonadotropin [β-hCG]) pregnancy test at screening and agree to further pregnancy tests per the protocol.
Practice at least 1 highly effective method of contraception; if oral contraceptives are used, a barrier method of contraception must also be used.
Female participants (pre- or perimenopausal) must use the appropriate highly effective, non-hormonal contraception method within 28 days of the first dose of study treatment, until 7 months after the last dose of study treatment (or longer based on companion drug). Highly effective methods of contraception are those methods that can achieve a failure rate of less than 1% per year when used consistently and correctly are considered as highly effective birth control methods. Such methods include:
i. intrauterine device (IUD) ii. bilateral tubal occlusion iii. vasectomized partner iv. sexual abstinence (i.e., refraining from heterosexual intercourse during the study treatment and 120 days after the last dose of study treatment).
e. Unacceptable contraception methods: Periodic abstinence (calendar, symptothermal, post-ovulation methods), withdrawal (coitus interruptus), spermicides only, and lactational amenorrhoea methods are not acceptable methods of contraception. Female condom and male condom should not be used together.

You may not qualify if…

Prior treatment with a SERD.
Prior treatment with more than two lines of chemotherapy for metastatic disease, including antibody drug conjugates.
Untreated and/or active CNS metastases.
History of other malignancies within the past 5 years (except adequately treated non-melanoma skin cancer or carcinoma in situ of the cervix).
Inability to take oral medications, refractory or chronic nausea, gastrointestinal conditions (including significant gastric or bowel resection), history of malabsorption syndrome, or any other uncontrolled gastrointestinal condition that impact the absorption of the study drug
Known intolerance to elacestrant or any of its excipients
Uncontrolled active infection or intercurrent illness.
Patients with known HBV and/or HCV infection must have undetectable viral load during screening (See Appendix B).
Patients known to be HIV+ are allowed if they have undetectable viral load at baseline.
Patients who are on any of the prohibited medications listed in sections 7.6 and 7.4.
Male participants will not be included because Male breast cancer is rare and may differ biologically and hormonally, which would introduce heterogeneity difficult to address in a small, single arm phase II trial.

Where it is running

NYU Langone Health — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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