Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial

Recruiting now · Phase 4

Conditions studied: Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine

In brief

After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.

Key facts

Study ID

NCT07611890

Run by

Rawalpindi Institute of Cardiology

People needed

70

Starts

2026-05-21

Expected to finish

2026-08-21

Last updated by the study team

2026-05-28

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events

You may not qualify if…

• Patients with known hypersensitivity to dexmedetomidine and Lignocaine.
• Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).
• Pregnant or lactating women.
• Patients with a history of airway anomalies or difficult intubation.

Where it is running

• Rawalpindi Institute of Cardiology — Rawalpindi, Punjab Province, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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