PRESERVE: LUPKYNIS in Combination With Belimumab, Obinutuzumab or Anifrolumab in Patients With Lupus Nephritis

Recruiting now · Phase 4

Conditions studied: Lupus Nephritis

In brief

The goal of this clinical study is to assess the efficacy and safety of LUPKYNIS® in combination with belimumab, obinutuzumab or anifrolumab at inducing rapid renal response in patients with lupus nephritis (LN).

Key facts

Study ID

NCT07611214

Run by

Aurinia Pharmaceuticals Inc.

People needed

150

Starts

2026-04-22

Expected to finish

2029-03-02

Last updated by the study team

2026-08-03

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Purushotham & Akther Kotha MD, Inc. — La Mesa, California, United States (enrolling)
• Valerius Medical Group & Research Center of Greater Long Beach, Inc. — Los Alamitos, California, United States (enrolling)
• Western Nephrology & Metabolic Bone Disease, PC — Arvada, Colorado, United States (enrolling)
• Swati Shah MD Rheumatology, LLC — Jacksonville, Florida, United States (enrolling)
• Vida Clinical Research — Kissimmee, Florida, United States (enrolling)
• Life Clinical Trials — Margate, Florida, United States (enrolling)
• CTR Oakwater — Orlando, Florida, United States (enrolling)
• Parris and Associates Rheumatology — Lawrenceville, Georgia, United States (enrolling)
• Accurate Clinical Research, Inc. — Lake Charles, Louisiana, United States (enrolling)
• Arthritis and Rheumatism Associates — Rockville, Maryland, United States (enrolling)
• Kansas City Physician Partners — Kansas City, Missouri, United States (enrolling)
• University of Nevada Las Vegas — Las Vegas, Nevada, United States (enrolling)
• Sahni Rheumatology & Therapy — West Long Branch, New Jersey, United States (enrolling)
• Buffalo Rheumatology and Medicine, PLLC — Orchard Park, New York, United States (enrolling)
• Arthritis and Osteoporosis Consultants of the Carolinas — Charlotte, North Carolina, United States (enrolling)
• Joint and Muscle Research Institute — Charlotte, North Carolina, United States (enrolling)
• Rheumatic Disease Associates, Ltd. — Willow Grove, Pennsylvania, United States (enrolling)
• Dunes Clinical Research — Dakota Dunes, South Dakota, United States (enrolling)
• West Tennessee Research Institute — Jackson, Tennessee, United States (enrolling)
• Novel Research LLC — Bellaire, Texas, United States (enrolling)
• Liberty Research Center — Dallas, Texas, United States (enrolling)
• Texas Arthritis Center — El Paso, Texas, United States (enrolling)
• Integrative Rheumatology of South Texas — Harlingen, Texas, United States (enrolling)
• Northwest Houston Arthritis Center — Houston, Texas, United States (enrolling)
• Texas Tech University Health Science Center — Lubbock, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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