Comparative Effectiveness of Alginate, Magaldrate, Sucralfate, Proton Pump Inhibitors, and Diet in Laryngopharyngeal Reflux Disease
Starting soon · Phase 4
Conditions studied: Laryngopharyngeal Reflux Disease
In brief
The goal of this randomized controlled trial is to compare the effectiveness of different treatments for laryngopharyngeal reflux disease (LPRD) in adult patients with confirmed symptoms and signs of the condition. The main question it aims to answer is: Which treatment (Proton Pump Inhibitors (PPIs), alginate, magaldrate, sucralfate, or diet) leads to the greatest improvement in LPRD symptoms and clinical signs over 3 months? Researchers will compare proton pump inhibitors to alternative medical treatments and dietary management to see which approach is most effective and better tolerated. Participants will: * undergo a clinical ENT examination with scoring of reflux signs (RSA) * complete symptom questionnaires (RSS) assessing severity, frequency, and impact of symptoms * receive one of the study treatments (medication or dietary intervention) * be evaluated at baseline and again after 3 months of treatment
Key facts
- Study ID
- NCT07611162
- Run by
- University of Mons
- People needed
- 800
- Starts
- 2026-05-01
- Expected to finish
- 2030-05-01
- Last updated by the study team
- 2026-05-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Positive 24-h HEMII-pH > 1 event
You may not qualify if…
- Smoker (>5 cigarettes/day) , alcohol dependence (>3 units/day),
- upper respiratory tract infection within the last month,
- pregnancy,
- neurological or psychiatric illness,
- previous history of neck surgery or trauma,
- malignancy,
- history of head and neck radiotherapy
- active seasonal allergies or asthma.
Where it is running
- University of Mons — Mons, Belgium
Full record on ClinicalTrials.gov
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