Periodontal Inflammation and Epigenetics in Obese Individuals
Starting soon · Not applicable
Conditions studied: Obesity, Periodontitis
In brief
The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are: • To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.
Key facts
- Study ID
- NCT07610902
- Run by
- Louisiana State University Health Sciences Center in New Orleans
- People needed
- 40
- Starts
- 2026-05-25
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-05-28
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged ≥18 years,
- No history of periodontal therapy in the last 6 months,
- No use of tobacco,
- No history of pregnancy lactation or contraceptive medication.
- Need to have a minimum of 20 teeth.
You may not qualify if…
- Had antimicrobial/antiviral therapy in the previous 3 months,
- History of uncontrolled diabetes,
- History of rheumatoid arthritis,
- History of osteoporosis,
- History of oral cancer,
- Currently taking hormonal contraception,
- If pregnant or lactating currently or prior 6 months,
- Subjects on current weight loss drugs
- If planning weight reduction surgery during the time of the study
- Any other condition, disease or therapy with documented influence on oral inflammation and/or oral microbial environment.
Where it is running
- LSU Health Science Centre, School of Dentistry — New Orleans, Louisiana, United States
Full record on ClinicalTrials.gov
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