guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing
Recruiting now · Not applicable
Conditions studied: Prenatal Genetic Diagnosis
In brief
This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal. Genome sequencing can examine nearly all of a baby's genes and may find genetic conditions that standard tests do not detect. Researchers will compare this test with current prenatal testing to see if it provides helpful information for families and doctors. The study will also explore how parents decide what kinds of genetic information they want to receive and how this information affects their experience during pregnancy. The goal is to understand whether genome sequencing can be used in a way that is helpful, responsible, and supportive for families in the future.
Key facts
- Study ID
- NCT07610590
- Run by
- Columbia University
- People needed
- 1042
- Starts
- 2026-04-29
- Expected to finish
- 2029-07-31
- Last updated by the study team
- 2026-07-15
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patient planned chorionic villus sampling (CVS) or amniocentesis in the absence of major fetal structural anomalies (minor anomalies are eligible, the HPO (Human Phenotype Ontology) will not be used by the analyst)
- Certified genetic counselor involved in care
You may not qualify if…
- A major structural anomaly
- Maternal or paternal age less than 18 years old
- Parental unwillingness to participate in 1 year of postnatal follow-up
- Language barrier (non-English or Spanish speaking)
Where it is running
- Columbia University Irving Medical Center (CUIMC) — New York, New York, United States (enrolling)
- Boston Childrens Hospital — Boston, Massachusetts, United States
- New York Genome Center — New York, New York, United States
Full record on ClinicalTrials.gov
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