AI-Assisted Optimization of Online Adaptive Radiotherapy for Gastric Lymphoma
Starting soon · Not applicable
Conditions studied: Lymphoma of the Mucosa Associated Lymphoid Tissue (MALT)
In brief
The goal of this clinical trial is to evaluate CBCT image-based triggered online adaptive radiotherapy (ART) and assess its clinical benefits in protecting organs at risk (OARs).
Key facts
- Study ID
- NCT07609355
- Run by
- Sun Yat-sen University
- People needed
- 25
- Starts
- 2026-05-08
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-05-27
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- ECOG Performance Status: 0 or 1, with no deterioration within the 2 weeks prior to enrollment.
- Age: ≥18 years and ≤75 years.
- Diagnosis \& Stage: Pathologically confirmed primary gastric lymphoma, staged as I, II, or IIE according to the Lugano modified staging system.
- Treatment Plan: Deemed by both medical oncology and radiation oncology physicians to be candidates for definitive radiotherapy or consolidative radiotherapy following chemotherapy, based on assessment prior to enrollment.
- Adequate Organ Function (including Bone Marrow Function, Hepatic Function, Coagulation Function, Renal Function, Cardiac Function)
- Informed Consent \& Compliance: Voluntarily participate, provide written informed consent, and be willing and able to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures.
You may not qualify if…
- Known history of malignancy (excluding patients with basal cell carcinoma of the skin, superficial bladder cancer, cutaneous squamous cell carcinoma, carcinoma in situ, or papillary thyroid carcinoma who have undergone curative surgery).
- Prior abdominal or pelvic radiotherapy within the past 3 years. Women who are pregnant or breastfeeding (women of childbearing potential must consider pregnancy testing; effective contraception must be emphasized during treatment).
- Inability to undergo contrast-enhanced magnetic resonance imaging (MRI) due to factors such as allergy to MRI contrast agents or claustrophobia.
- Any other disease or clinically significant laboratory abnormality, severe medical or psychiatric condition/disorder, or substance abuse (including alcohol abuse) considered by the investigator as potentially compromising patient safety, the integrity of the study, patient participation, or interfering with the study objectives and analysis of results.
Where it is running
- Sun Yat-sen University Cancer Center — Guangzhou, Guangdong, China
Full record on ClinicalTrials.gov
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