TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of Bone

Recruiting now

Conditions studied: Giant Cell Tumor of Bone, TRACP-5b, Disease Surveillance and Monitoring, Tartrate-Resistant Acid Phosphatase 5b

In brief

This prospective observational study will evaluate whether the blood biomarker TRACP-5b can help diagnose and monitor patients with giant cell tumor of bone (GCTB). GCTB is a rare but locally aggressive bone tumor that can return even after surgical treatment. Currently, patients require long-term follow-up based mainly on imaging examinations such as CT or MRI, and suspected recurrence often requires invasive biopsy procedures. TRACP-5b is an enzyme associated with osteoclast activity that can be measured from a blood sample. Previous studies suggest that TRACP-5b levels may reflect disease activity and risk of recurrence in patients with GCTB. In this study, patients with newly diagnosed GCTB and patients already undergoing long-term follow-up after treatment will undergo regular blood sampling for TRACP-5b measurement during routine outpatient visits. Laboratory results will be compared with the patient's clinical condition, imaging findings, and histological results when available. The goal of the study is to determine whether TRACP-5b could become a reliable and minimally invasive tool for earlier detection of disease recurrence and improved long-term monitoring of patients with giant cell tumor of bone.

Key facts

Study ID: NCT07609277
Run by: St. Anne's University Hospital Brno, Czech Republic
People needed: 70
Starts: 2026-01-01
Expected to finish: 2028-05-31
Last updated by the study team: 2026-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Histologically confirmed Giant Cell Tumor of Bone
Newly diagnosed patients or patients undergoing long-term follow-up after previous treatment
Age ≥18 years
Ability to understand the study procedures and provide written informed consent

You may not qualify if…

Concurrent diseases significantly affecting bone metabolism, including metabolic bone disorders
Inability or unwillingness to provide informed consent
Patients unable to comply with routine follow-up procedures
Active conditions that may substantially influence serum TRACP-5b levels independently of Giant Cell Tumor of Bone evaluation

Where it is running

First Department of Orthopaedic Surgery, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czechia — Brno, Czechia (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.