Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Stroke, Aphasia

In brief

This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.

Key facts

Study ID

NCT07608588

Run by

University of South Carolina

People needed

45

Starts

2026-05-15

Expected to finish

2027-07-30

Last updated by the study team

2026-05-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Right-handedness (assesed using the Edinburgh Handedness Inventory)
• Native English speakers
• Single left hemispheric stroke
• Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician

You may not qualify if…

• Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)
• Major phonological impairments (defined as > 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)
• Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)
• Contraindication to MRI
• Stroke involving the left ATL
• Severe depression or psychiatric history
• Illiteracy
• Known neurodegenerative disorders
• Severe uncorrected visual or hearing impairments

Where it is running

• McCausland Center — Columbia, South Carolina, United States (enrolling)

Full record on ClinicalTrials.gov

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