Impact of NOL - Nociception Level Index Intraoperative Monitoring on Perioperative Outcomes in Spine Surgery - a Quality Improvement Pilot

Starting soon · Not applicable

Conditions studied: Spine Surgery, Pain After Surgery, Anesthesia , Analgesia

In brief

The objective of this study is to evaluate the clinical impact of the NOL nociception level index monitoring on intraoperative and post operative patient outcomes and institutional metrics when used to guide intraoperative analgesia dosing in patients undergoing spine surgery under general anesthesia when compared to a case controlled retrospective cohort.

Key facts

Study ID

NCT07608276

Run by

Medasense Biometrics Ltd

People needed

100

Starts

2026-05-01

Expected to finish

2027-03-01

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 18 years old.
• ASA I-III
• Elective spine surgery (laminectomy, spinal fusion, and disc replacement) under general anesthesia.
• Opioid tolerant and patients with documented chronic pain may be included
• Patient able to provide informed consent

You may not qualify if…

• • Use of any type of anesthesia other than general anesthesia (neuraxial, epidural analgesia or local regional anesthesia)
• Use of intraoperative methadone
• Non-sinus heart rate
• Pregnancy/lactation
• Chronic use of psychoactive drugs within 90 days prior to surgery
• Patients currently using IV opioids (IV drug abuse)
• Allergy or intolerance to any of the study anesthesia related drugs
• History of severe cardiac arrhythmias within the last 12 months
• Surgeries less than 1.5 hours (from incision to extubation)

Where it is running

• Thomas Jefferson University Hospital — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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