Spinal Cord Associative Plasticity in Cerebral Palsy
Recruiting now · Not applicable
Conditions studied: Hemiplegic Cerebral Palsy
In brief
Associative plasticity has been used to promote functional recovery from conditions affecting movement. The long term goal of this project is to use electrical stimulation techniques to improve arm and hand function. The goal of this prospective experimental study in adults with hemiplegic cerebral palsy (hCP) is to test the effects of pairing hand motor cortical and median nerve stimulation targeted to induce plasticity in the cervical spinal cord. Based on preliminary data in neurotypical adults, the investigators are testing the effects of this approach in adults with hCP. This study will first verify the present stimulation parameters as sufficient to promote induction of associative plasticity of sensorimotor connections for manual dexterity in adults with hCP. This will be assessed through neurophysiological, biomechanical, and clinical functional outcome measures. Successful pairing showing meaningful improvements in dexterity could then be used as an impetus for a larger study examining the efficacy of SCAP in people with hCP.
Key facts
- Study ID
- NCT07607665
- Run by
- Columbia University
- People needed
- 25
- Starts
- 2026-06-01
- Expected to finish
- 2032-05-01
- Last updated by the study team
- 2026-05-28
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Maintenance of caffeine and exercise levels at time of sessions
- Ability to provide informed consent
- Manual ability classification system (MACS) level I to III
You may not qualify if…
- History of seizures in last two years
- Use of medications that lower seizure threshold
- History of implanted equipment including stimulators/pacemakers
Where it is running
- Columbia University Irving Medical Center — New York, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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