Effect of Liposomal Bupivacaine on Rebound Pain After Peripheral Nerve Block in Orthopedic Surgery.

Starting soon · Phase 4

Conditions studied: Acute Pain, Orthopaedic Surgery

In brief

This study will prospectively compare the preventive effect of liposomal bupivacaine combined with plain bupivacaine versus plain bupivacaine alone on rebound pain after nerve block in patients undergoing orthopedic extremity surgery. The primary aim is to assess whether the combination reduces the incidence or severity of rebound pain (i.e., more effectively covers the postoperative inflammatory peak on days 2-3 and provides a smoother regression curve of sensory blockade). Secondary aims include evaluation of upper limb functional scores, occurrence of chronic pain, and health-related quality of life. All aims will be assessed over 72 hours or the duration of hospitalization if shorter.

Key facts

Study ID

NCT07606911

Run by

Shanghai Jiao Tong University Affiliated Sixth People's Hospital

People needed

668

Starts

2026-07-01

Expected to finish

2027-12-01

Last updated by the study team

2026-06-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18-65 years old;
• ASA Physical Status 1-3;
• Scheduled for elective unilateral orthopedic surgery of the upper or lower extremity.

You may not qualify if…

• Women who are pregnant or breastfeeding;
• Bupivacaine sensitivity or known allergy;
• Contraindication for nerve blocks;
• Enrollment in another clinical trial that could confound pain evaluation;
• Other conditions that preclude study participation.

Where it is running

• Shanghai sixth people's hospital — Shanghai, Shanghai Municipality, China

Full record on ClinicalTrials.gov

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