Blast Overpressure Longitudinal Study

Starting soon

Conditions studied: Low-level Blast Exposure

In brief

The goal of this observational study is to learn about the impact of low-level blast exposure in U.S. Special Operations Forces personnel. The main questions it aims to answer are: What advanced brain imaging changes are related to clinical presentation after low-level blast exposure? What are the relationships between low-level blast exposure and common groups of symptoms after concussion? Participants will: * Undergo advanced brain imaging * Answer questionnaires * Complete clinical tests * Provide blood, urine, and saliva samples * Wear blast sensors

Key facts

Study ID

NCT07606651

Run by

Uniformed Services University of the Health Sciences

People needed

250

Starts

2026-05-01

Expected to finish

2030-08-01

Last updated by the study team

2026-05-26

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Active duty
• U.S. SOF personnel
• 18-50 years old

You may not qualify if…

• Subjects will be excluded only if their participation will significantly interfere with validity of data collection or safety during the study (e.g., they have conditions that might result in harm or injury during research procedures).
• Example: pregnancy (balance considerations)
• Example: being unable to undergo MRI testing (i.e., they have non-MRI compatible devices, imbedded metal fragments such as shrapnel, and/or severe claustrophobia; these MRI contraindications will be screened using an MRI Safety Questionnaire)

Where it is running

• Walter Reed National Military Medical Center — Bethesda, Maryland, United States
• Fort Bragg — Fort Bragg, North Carolina, United States
• Wilford Hall Ambulatory Surgical Center — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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