Denys-Drash Syndrome and Risk of Post-transplant Lymphoproliferative Disorder

Starting soon

Conditions studied: Denys-Drash Syndrome

In brief

Denys-Drash syndrome is a rare genetic disorder of childhood characterized by nephrotic syndrome, nephroblastomas, and genital developmental abnormalities. These children present with rapidly progressive renal failure, leading to kidney transplantation at a median age of 3.6 years. In a study of the French cohort of patients with Denys-Drash syndrome, a high risk of lymphoproliferative syndrome was observed (20%). This frequency is significantly higher than in the general transplant population (4%). The aim of the study is to evaluate the risk of post-transplant lymphoproliferative disorder following kidney transplantation in patients with Denys-Drash syndrome compared to patients with kidney transplant patients without Denys-Drash syndrome.

Key facts

Study ID

NCT07605884

Run by

Assistance Publique - Hôpitaux de Paris

People needed

108

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-05-26

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient must be a minor at the time of kidney transplantation
• Diagnosis of Denys-Drash syndrome (WT1 pathogenic variants in exons 8 or 9) for cases
• Controls: minor patient, kidney transplanted at the same center as the case, immediately before and immediately after the case
• Kidney transplant recipient on immunosuppressants
• Hospital follow-up in a participating center in France
• Regardless of their Epstein-Barr virus status before transplantation
• Between 2000 and 2022
• Holders of parental authority or adult patients informed of the study and not objecting to the processing of medical data for the study

You may not qualify if…

• History of lymphoproliferative disorder prior to transplantation
• Other hematopoietic cancer
• Other genetic disease with a proven increased risk of lymphoproliferative disorder

Where it is running

• Hôpital Femme Mère Enfant, Hospices Civils de Lyon — Bron, France
• CHU de Lille — Lille, France
• CHU Montpellier — Montpellier, France
• CHU de Nancy - Hôpitaux de Brabois — Nancy, France
• Hôpital enfants et adolescents, CHU Nantes — Nantes, France
• Hôpital Necker-Enfants Malades — Paris, France
• Hôpital Robert Debré — Paris, France

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.