Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation

Recruiting now

Conditions studied: Degenerative Mitral Valve Disease

In brief

The goal of this observational study is to compare the outcomes of transcatheter edge-to-edge repair (TEER) versus surgical mitral valve repair for degenerative mitral regurgitation (DMR) over the long term. The study aims to: 1. Evaluate the effectiveness and safety of TEER versus surgery in patients with DMR over long term. 2. Investigate the predictors of left ventricular dysfunction and clinical outcomes using advanced imaging techniques, such as cardiac MRI 3. Assess patient-reported recovery and quality of life outcomes using validated tools. The study focuses on improving care strategies for patients with DMR, particularly those at higher surgical risk, by identifying optimal treatment approaches and predictors of recovery.

Key facts

Study ID

NCT07605715

Run by

Cedars-Sinai Medical Center

People needed

60

Starts

2025-02-19

Expected to finish

2027-08-01

Last updated by the study team

2026-05-26

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients older than 60 years who have DMR will be included in the study

You may not qualify if…

• Patients with prior history of mitral intervention or surgery will be excluded.
• Patient records flagged "break the glass" or "research opt out" will be excluded.
• Persons with allergy to animal dander or animal-instigated asthma will be excluded.

Where it is running

• Smidt Heart Institute, Cedars Sinai Medical Center — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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