Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age

Starting soon · Not applicable

Conditions studied: Male Infertility, Advanced Paternal Age, Assisted Reproductive Technology

In brief

Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF/ICSI cycles involving men aged 40 years or older

Key facts

Study ID

NCT07605182

Run by

Vietnam Military Medical University

People needed

378

Starts

2026-05-05

Expected to finish

2027-12-30

Last updated by the study team

2026-05-22

Who can join

Age: 40 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male partners aged ≥ 40 years
• Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million/mL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence.
• Female partners with ≥ 5 mature (MII) oocytes retrieved.
• Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET).
• Willingness to participate and sign informed consent.

You may not qualify if…

• Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm.
• Female uterine or ovarian conditions severely affecting IVF outcomes.
• Use of donor sperm or donor oocytes

Where it is running

• Vietnam Military medical university — Hà Nội, Ha Dong, Vietnam

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.