A Study to Assess the Safety, Tolerability and Efficacy of ION775

Recruiting now · Phase 2

Conditions studied: Hypertriglyceridemia, Severe Hypertriglyceridemia

In brief

The main objective of this study is to evaluate the effect of ION775 on fasting triglyceride (TG) levels in participants with hypertriglyceridemia (HTG) and severe hypertriglyceridemia (sHTG).

Key facts

Study ID

NCT07604974

Run by

Ionis Pharmaceuticals, Inc.

People needed

72

Starts

2026-05-12

Expected to finish

2028-03-01

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Ionis Investigative Site — Lincoln, California, United States (enrolling)
• Ionis Investigative Site — Aurora, Colorado, United States (enrolling)
• Ionis Investigative Site — Boca Raton, Florida, United States (enrolling)
• Ionis Investigative Site — Miami, Florida, United States (enrolling)
• Ionis Investigative Site — Miramar, Florida, United States (enrolling)
• Ionis Investigative Site — Columbus, Georgia, United States (enrolling)
• Ionis Investigative Site — Louisville, Kentucky, United States (enrolling)
• Ionis Investigative Site — Flint, Michigan, United States (enrolling)
• Ionis Investigative Site — Munroe Falls, Ohio, United States (enrolling)
• Ionis Investigative Site — Little River, South Carolina, United States (enrolling)
• Ionis Investigative Site — Houston, Texas, United States (enrolling)
• Ionis Investigative Site — Lampasas, Texas, United States (enrolling)
• Ionis Investigative Site — McKinney, Texas, United States (enrolling)
• Ionis Investigative Site — Mesquite, Texas, United States (enrolling)
• Ionis Investigative Site — San Antonio, Texas, United States (enrolling)
• Ionis Investigative Site — Québec, Canada (enrolling)

Full record on ClinicalTrials.gov

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