The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome
Recruiting now
Conditions studied: Tako Tsubo Cardiomyopathy, Microvascular Dysfunction, CD34+ Stem Cells, Heart Failure, Cardiac Contractility Recovery
In brief
The underlying mechanisms of microvascular dysfunction in Takotsubo cardiomyopathy remain incompletely understood. As CD34+ cells are essential to coronary microvascular homeostasis we will investigate the potential association between CD34+ cell count and changes in left ventricular function in patients with Takotsubo cardiomyopathy at baseline and 6-month follow-up.
Key facts
- Study ID
- NCT07604467
- Run by
- University Medical Centre Ljubljana
- People needed
- 40
- Starts
- 2021-09-06
- Expected to finish
- 2026-12-31
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Minimum age 18 years
- Established TTS per InterTak registry criteria
- Signed consent form
You may not qualify if…
- Patients under the age of 18 years
- Ischemic heart disease with at least one complete total occlusion
- Other concurrent cardiomyopathies
- Active infectious myocarditis
- obstructive coronary artery disease
- Previous hospital stay due to acute coronary syndrome (myocardial infarction) in the last 6 months before TTS acute event
- Previous interventional coronary artery procedure in the last 6 months before TTS acute event
- Significant valvular heart disease
- Significant peripheral artery occlusive disease
- Active or remitted hematologic malignancy
- Patients receiving immunosuppressive therapy
- Significant comorbiditeis affecting patients survival (malignancy)
- Failure to obtain freely given, informed consent form.
Where it is running
- Advanced Heart Failure and Transplantation Program, Department of Cardiology, UMC Ljubljana, Slovenia — Ljubljana, Ljubljana, Slovenia (enrolling)
Full record on ClinicalTrials.gov
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