The Effect of Different Intra-canal Medications on Postoperative Pain

Recruiting now · Early Phase 1

Conditions studied: Pulp Necrosis, Apical Periodontitis

In brief

The aim of this study is to assess the effect of ibuprofen, nitrofurantoin, and calcium hydroxide on postoperative pain after endodontic treatment of necrotic mandibular posterior teeth Research question/hypothesis: In patients with necrotic pulps in their mandibular posterior teeth, there would be no difference in the incidence and/or severity of postoperative pain after the use of ibuprofen, nitrofurantoin, or calcium hydroxide intracanal medications. The study will evaluate postoperative pain after using either of the tested drugs as an intracanal medication amidst visits. of endodontic treatment in cases where pulp necrosis is confirmed.

Key facts

Study ID

NCT07603934

Run by

Cairo University

People needed

111

Starts

2025-12-15

Expected to finish

2027-03-15

Last updated by the study team

2026-07-21

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with necrotic pulps.
• Adult, healthy patients, older than 18 years old
• Males and females.
• Patient with the ability to understand and use pain scales.
• Patient who accepts enroll to the study.

You may not qualify if…

• Patients' allergies or any other contraindication to any of the medications used.
• Pregnant and lactating females.
• Patients have been taking pain medication 12 hours earlier.
• Patients who have more than one symptomatic mandibular tooth in the same quadrant.
• Patients with contributory medical history (ASA>II).

Where it is running

• Faculty of Oral and Dental Medicine, Egyptian Russian University — Cairo, Cairo Governorate, Egypt (enrolling)

Full record on ClinicalTrials.gov

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