Immediate Electrophysiological Effects of Different Atrial Pacing Sites on P-Wave Characteristics

Recruiting now · Not applicable

Conditions studied: Pacing Therapy, Cardiac Pacing

In brief

This is a prospective, single-center, non-randomized, within-subject interventional study. The purpose is to compare the immediate effects of different atrial pacing sites on atrial electrical activation, as reflected by P-wave characteristics on surface electrocardiography (ECG). During pacemaker implantation, short-term pacing will be performed sequentially at multiple predefined atrial sites, including the right atrial appendage (RAA), atrial septum, Bachmann's bundle (BB) area, and posterosuperior bundle (PSB) regions. ECG parameters will be recorded at each site to evaluate differences in P-wave duration and morphology.

Key facts

Study ID

NCT07603648

Run by

Shanghai Tong Ren Hospital

People needed

35

Starts

2026-03-31

Expected to finish

2026-10-31

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Sinus rhythm at baseline
• Indication for permanent pacemaker implantation with planned atrial lead placement
• Willing and able to provide written informed consent

You may not qualify if…

• Long-standing persistent or permanent atrial fibrillation, or prior atrioventricular node ablation
• Prior cardiac implantable electronic device (CIED) requiring revision, replacement, or upgrade
• Indication for implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy defibrillator (CRT-D)
• Significant valvular heart disease, cardiomyopathy, or prior cardiac surgery
• Angina or acute myocardial infarction within 3 months before enrollment
• Chronic use of antiarrhythmic drugs
• Severe hepatic or renal dysfunction, or other serious systemic diseases
• Participation in another clinical study that may interfere with the objectives of this study

Where it is running

• Tong Ren Hospital, Shanghai Jiaotong University School of Medicine — Shanghai, Shanghai Municipality, China (enrolling)
• Affiliated Hospital of Zunyi Medical College — Zunyi, Guizhou, China

Full record on ClinicalTrials.gov

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