Multi-Omics Insights Into Androgenetic Alopecia

Recruiting now

Conditions studied: Androgenetic Alopecia (AGA)

In brief

This study utilizes a multi-omics approach to systematically characterize the cellular heterogeneity and spatial architecture of the hair follicle microenvironment in patients with androgenetic alopecia (AGA). Our primary aim is to elucidate the key mechanisms driving hair follicle stem cell (HFSC) exhaustion and to identify potential therapeutic targets. Investigators will collect six groups of scalp tissue samples, which include healthy controls and AGA patients (stratified into younger and older cohorts). By integrating spatial transcriptomics, single - cell sequencing data, investigators will map aberrant cell subpopulations and their complex interaction networks. Furthermore, the identified core targets will be functionally validated using patient-derived organoids and animal models. Expected outcomes include the identification of 3-5 critical cell subpopulations and the discovery of 8-10 disease-associated targets. Additionally, investigators will establish an integrated clinical-omics-validation database, providing a robust theoretical foundation for the precision diagnosis and treatment of AGA.

Key facts

Study ID

NCT07603544

Run by

The First Affiliated Hospital of Xinxiang Medical College

People needed

12

Starts

2026-03-08

Expected to finish

2027-03-01

Last updated by the study team

2026-06-15

Who can join

Age: 20 and older, up to 65. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Age and Gender: Males aged 25-30 or 60-65 years.
• Diagnosis: Patient Group: Diagnosed by a physician with Hamilton-Norwood Stage III androgenetic alopecia (AGA). Healthy Control Group: Healthy scalp with no signs of hair loss.
• Medication and Treatment History: No use of anti-hair loss medications (e.g., minoxidil, finasteride), hormonal drugs, or scalp chemical treatments (perm or dye) within the last 6 months.
• Informed Consent: Voluntarily signed and provided written informed consent.

You may not qualify if…

• Scalp Conditions: Presence of other types of alopecia (besides AGA) or active scalp diseases (e.g., psoriasis, dermatitis, infections).
• Medical History: History of keloids or coagulation disorders.
• Systemic Diseases: Major underlying conditions, including severe cardiovascular/cerebrovascular diseases, immune system disorders, or malignant tumors.
• Allergies: Known hypersensitivity to local anesthetics.
• Prior Clinical Trials: Participation in any other clinical trials within 3 months prior to screening.
• Other Factors: Any other conditions deemed unsuitable for participation by the investigator.

Where it is running

• The First Affiliated Hospiatl of Henan Medical University — Xinxiang, Henan, China (enrolling)

Full record on ClinicalTrials.gov

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