Assessment of Venous Insufficiency and Clinical Features in Lipedema

Recruiting now

Conditions studied: Lipedema, Venous Insufficiency, Venous Disease, Disability Physical

In brief

Lipedema is a chronic adipose tissue disorder characterized by disproportionate fat accumulation, pain, tenderness, edema, and functional impairment. Venous symptoms such as heaviness, swelling, and discomfort are frequently reported in individuals with lipedema; however, the relationship between venous Doppler ultrasonography findings and lipedema-related clinical manifestations remains insufficiently investigated. This cross-sectional controlled study aims to evaluate venous insufficiency parameters in patients with lipedema using Doppler ultrasonography and to examine their associations with pain severity, lower extremity function, disease severity, and quality of life.

Key facts

Study ID

NCT07603076

Run by

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

People needed

82

Starts

2026-06-20

Expected to finish

2026-08-01

Last updated by the study team

2026-07-14

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female participants aged 18 years or older
• Clinically diagnosed lipedema according to established diagnostic criteria
• Ability to provide written informed consent
• Ability to complete clinical assessments and questionnaires

You may not qualify if…

• History of lower extremity venous surgery or sclerotherapy
• Known peripheral arterial disease
• Secondary lymphedema or other causes of lower extremity edema
• Active infection, cellulitis, or inflammatory disease affecting the lower extremities
• Pregnancy or postpartum period
• Neurological, rheumatological, or musculoskeletal disorders significantly affecting lower extremity function
• Malignancy or severe systemic disease
• Inability to undergo venous Doppler ultrasonography
• Inability to understand or complete study assessments and questionnaires

Where it is running

• Department of Physical Medicine and Rehabilitation, Health Sciences University Sultan Abdulhamid Han Training and Research Hospital — Istanbul, Uskudar, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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