The Effects of Nitrate-Rich Mouthwash on Vascular Tone
Starting soon · Not applicable · Has a placebo group
Conditions studied: Blood Pressure Regulation
In brief
High blood pressure (hypertension) is a major risk factor for cardiovascular disease. One important contributing factor to high blood pressure is reduced availability of nitric oxide (NO). Therefore, NO is an important molecule in maintaining healthy blood vessel function. Dietary nitrate, found in leafy greens, can serve as an alternative source of nitric oxide in the body. After ingestion, nitrate is converted to nitrite by bacteria residing in the oral cavity. Nitrite can subsequently be converted to NO when swallowed. Therefore, this nitrate-nitrite-nitric oxide pathway is dependent on oral bacteria. This study aims to assess whether rinsing the mouth with a nitrate-rich mouth rinse influences blood pressure in healthy adults. Also, concentrations of nitrate and nitrite in plasma and saliva will be measured following the nitrate-mouth rinse exposure.
Key facts
- Study ID
- NCT07602764
- Run by
- Göteborg University
- People needed
- 20
- Starts
- 2026-04-01
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-05-22
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- ≥18 years of age; and
- clinic blood pressure <140/<90 mmHg.
You may not qualify if…
- hypertension;
- systemic medication (other than the oral contraceptive pill);
- antibiotic treatment within the last 3 months;
- active smoking status and BMI > 30;
- prior gastric by-pass surgery;
- self-reported use of antiseptic mouthwash or toothpaste;
- self-reported use of tongue scrapes; and
- active periodontal disease or caries that needs treatment.
Where it is running
- Odontologen, University of Gothenburg — Gothenburg, Västra Götaland County, Sweden
Full record on ClinicalTrials.gov
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