The Impact of Blood Pressure Variability During the Induction and Surgical Periods on Postoperative Acute Kidney Injury

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Conditions studied: Acute Kidney Injury (AKI)

In brief

The goal of this multicenter retrospective cohort study aimed to explore the effect of BPV during anesthesia induction and surgery on the occurrence of postoperative AKI in non-cardiac surgery patients.

Key facts

Study ID

NCT07602465

Run by

Zhongda Hospital

People needed

5000

Starts

2026-06-01

Expected to finish

2026-12-01

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing non-cardiac surgery；
• Adult；

You may not qualify if…

• Undergoing urological surgeries that partially directly affect kidney function (including relief of urinary tract obstruction, nephrectomy, or kidney transplantation);
• Surgery duration less than 60 minutes;
• Weight < 30 kg or BMI > 35 kg/m2;
• Patients who underwent reoperation within 7 days after surgery;
• Surgeries not performed under general anesthesia;
• ASA > IV;
• No serum creatinine measurement available within 6 months before surgery (baseline value) or within 7 days after surgery;
• Preexisting renal dysfunction or a diagnosis of chronic kidney disease before surgery (creatinine > 443 μmol/L);
• No invasive blood pressure monitoring during the anesthesia induction period, or missing more than 25% of intraoperative invasive blood pressure data collection.

Full record on ClinicalTrials.gov

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