CAROTID ENDATORECTOMY AND GENERAL ANESTHESIA: Assessment and Evaluation of Cerebral Ischemic Damage With Clinical, Laboratory and Imaging Parameters

Starting soon

Conditions studied: Carotid Artery Stenosis, Endarterectomy, Carotid, Ischemic Cerebrovascular Accident

In brief

This study is aiming to provide us with information about the neuroprotective effect of two commonly used anesthetic drugs, during carotid endarterectomy. A day before sugery, a brain MRI will be performed as well as a cognitive function assessment test. The day of the surgery each patient will receive anesthesia either by using intravenous anesthetic drug or an inhalation agent and during the intraoperative period, the Anesthesiologist will draw a small amount of blood in three different times in order to measure brain biomarkers. A day after the surgery, a second brain MRI will be performed as well as a second cognitive function assessment test and their results will be compared to the preoperative ones. The study will focus on whether there is a higher incidence of microischemic brain lesions shown in imaging tests or whether cognitive function is impaired postoperative or whether brain biomarkers indicating brain damage are elevayed with any of these drugs and thus conclude which one shows or not a neuroprotective effect, with the condition that no change in the regular anesthesia management was made and no danger was imposed on the patient.

Key facts

Study ID

NCT07602400

Run by

University Hospital of Patras

People needed

160

Starts

2026-05-30

Expected to finish

2027-12-01

Last updated by the study team

2026-05-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years
• ASA 1-4
• For planned carotid endarterectomy
• Absence of major established neurological deficits that would not allow neurological evaluation and performance of the MoCA test
• Patient consent to participate in the study

You may not qualify if…

• Age ≤ 18 years
• Presence of major neurological deficits that will not allow neurological evaluation and performance of the MoCA test
• Claustrophobia and inability to enter the MRI scanner
• Cochlear implants
• Intracranial vascular clips
• Neurostimulation systems
• Pacemaker incompatible for MRI
• Small cell and non-small cell lung cancer
• Neuroendocrine tumors
• Melanoma
• Seminoma
• Teratoma
• Malignant pheochromocytoma
• CNS or NM diseases
• Schizophrenia
• Allergy or contraindication to any anesthetic factor
• Patient refusal to participate in the study

Full record on ClinicalTrials.gov

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