The Effect of Nerve Blocks on Analgesia in Breast Cancer Surgery

Starting soon · Not applicable

Conditions studied: Breast Cancer Surgery Pain

In brief

Postoperative pain following modified radical mastectomy remains a significant clinical concern and may adversely affect patient recovery, opioid consumption, and overall patient satisfaction. Ultrasound-guided regional anesthesia techniques have gained increasing importance as part of multimodal analgesia strategies in breast surgery. The serratus anterior plane (SAP) block is a commonly used interfascial plane block for postoperative analgesia in thoracic and breast procedures. Recently, the serratus posterior superior intercostal plane (SPSIP) block has emerged as a novel regional anesthesia technique with potentially wider thoracic dermatomal spread and effective analgesic properties. This prospective randomized controlled study aims to compare the postoperative analgesic efficacy of the SPSIP block and SAP block in patients undergoing modified radical mastectomy under general anesthesia. Patients will be randomly allocated into two groups to receive either ultrasound-guided SPSIP block or SAP block preoperatively. Primary outcomes will include postoperative pain scores and opioid consumption within the first 24 hours after surgery. Secondary outcomes will include time to first analgesic request, rescue analgesic requirements, intraoperative hemodynamic parameters, postoperative nausea and vomiting, block-related complications, and patient satisfaction. The study is designed to evaluate whether SPSIP block provides superior postoperative analgesia compared with SAP block in modified radical mastectomy surgery.

Key facts

Study ID

NCT07601490

Run by

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

People needed

70

Starts

2026-06-15

Expected to finish

2026-10-16

Last updated by the study team

2026-05-27

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged between 18 and 65 years
• American Society of Anesthesiologists (ASA) physical status I-III
• Body Mass Index (BMI) <35 kg/m²
• Normal International Normalized Ratio (INR) value and platelet count
• Normal liver and renal function tests
• Patients scheduled for elective modified radical mastectomy surgery

You may not qualify if…

• Bleeding diathesis
• Allergy to local anesthetic agents
• Suspected infection or inflammation at the planned block site
• ASA physical status IV or higher
• Long-term medication use due to chronic pain
• Advanced hepatic or renal failure
• Presence of severe pulmonary disease
• Use of any opioid medication within 24 hours before surgery
• Cognitive impairment
• Patients undergoing revision surgery

Where it is running

• Health Sciences University 2. Sultan Abdülhamid Han Training and Research Hospital — Istanbul, Uskudar, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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